Evolving Innovative Solutions™ - Since 1993
Natural Selection, Inc. has unique expertise in the application of a diverse range of computational intelligence methods applied to bioinformatics problems. Natural Selection, Inc. has experience in the following areas:
In collaboration with Eli Lilly & Company, Natural Selection, Inc. used evolutionary computation to find transcription factor binding sites in co-expressed genes. This software tool (known as BEAGLE) has been demonstrated to be useful even when the sequences of the transcription factor binding sites are not known in advance, leading to the discovery of entirely novel binding sites. The method was extended to work for the discovery of composite transcription factor binding sites.
In collaboration with Isis Pharmaceuticals, Natural Selection, Inc. developed software to search for common RNA structures in human pathogens using an evolutionary algorithm. This approach demonstrated the opportunity to search tremendous spaces of possible RNA structures and rapidly identify RNA motifs shared by multiple organisms.
Natural Selection, Inc. has worked with several commercial customers for pattern recognition from microarray data leading to cancer diagnostics. Natural Selection's tools allow for simultaneous feature reduction and model optimization.
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