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Oct 18, 2007

Dr. Gary Fogel Co-authors Article on Anti-malarial drug screening in the Journal of Molecular Graphics and Modeling

San Diego, CA - The October issue of the Journal of Molecular Graphics and Modeling features an article co-authored by Dr. Gary Fogel, Vice President and Mars Cheung, Staff Scientist of Natural Selection, Inc. together with Dr. David Hecht and Eric Pittman of Southwestern College. The article is entitled "In Silico Screening Against Wild-type and Mutant Plasmodium falciparum Dihydrofolate Reductase." The article presents modeling studies for a series of dihydrofolate reductase (DHFR) inhibitors to better understand the differences and similarities of binding of these inhibitors between wild-type and resistant strains of the malarial parasite Plasmodium falciparum. “While malaria continues to evolve resistance to known inhibitors, studies like this will help to decipher the mechanisms of resistance so that future high-throughput screening experiments can focus on compounds that are likely to be active against both wild-type and resistant strains,” said Dr. Fogel.

The article and supplementary material can be found at:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TGP-4PXM6H4-1

Natural Selection, Inc. was founded in 1993 to address complex problems in industry, medicine, and defense. The company possesses unique expertise in computational intelligence techniques, including evolutionary computation, neural networks, and fuzzy logic. The corporation's research efforts support the discovery of new pharmaceuticals, the automated detection and discovery of important patterns and processes in bioinformatics and medical informatics, computer-assisted diagnosis, and a variety of military and industrial projects.

For more information, please contact:

Dr. Gary B. Fogel
Vice President
Natural Selection, Inc.
9330 Scranton Rd.
Suite 150
San Diego, CA, 92121
tel: (858) 455-6449
fax: (858) 455-1560
gfogel@natural-selection.com

and please visit our web site at http://www.natural-selection.com/.