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Natural Selection, Inc. Publishes Statistical Analysis of Transcription Factor Database in BioSystems
La Jolla, CA – As part of a collaborative effort, Dr. Gary B. Fogel, Vice President of Natural Selection, Inc., has published a paper titled "A statistical analysis of the TRANSFAC® database" in the journal BioSystems. Transcription factors are key regulatory elements that control gene expression. A statistical analysis of all known transcription factor families in the TRANSFAC® database is presented. The analysis suggests that current definition of transcription factor binding site core regions in TRANSFAC® should be re-examined so as to capture a more precise notion of "cores." Insight is offered into more appropriate definitions of transcription factor binding site consensus sequences and core regions. These revised definitions provide a better understanding of the nature of transcription factor-DNA binding and assist with developing algorithms for de novo transcription factor binding site discovery.
Natural Selection, Inc. was founded in 1993 to address complex problems in industry, medicine, and defense. The company possesses unique expertise in computational intelligence techniques, including evolutionary computation, neural networks, and fuzzy logic. The corporation's research efforts support the discovery of new pharmaceuticals, the automated detection and discovery of important patterns and processes in bioinformatics and medical informatics, computer-assisted diagnosis, and a variety of military and industrial projects.
For more information, please contact:
Dr. Gary B. Fogel
Vice President
Natural Selection, Inc.
3333 N. Torrey Pines Ct.
Suite 200
La Jolla, CA, 92037
tel: (858) 455-6449
fax: (858) 455-1560
gfogel@natural-selection.com
and please visit our web site at http://www.natural-selection.com/.